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Uncoated Metal
Scanning electron micrograph of the uncoated surface
showing areas with a dense layer of blood proteins
and formed elements, covered with fibrin strands.
Platelets are activated, leading to the characteristic
hedgehog-like shape shown in the image on the right.
Scanning electron micrograph of the silicon carbide
coated surface showing areas with thrombi and
erythrocytes, but not densely packed or covered with
fibrin. Platelets remain resting, which can be seen
in the corresponding round shape of the platelet in
the image on the right.
Silicon Carbide Coated
PROBIO
®
coated metal encourage a continuous endothelial layer to form on its surface.
A sound endothelial layer interacts passively with proteins and platelets. Uncoated metal
does not show the same endothelial development as coated.
Facilitates Complete Endothelialization
4
A barrier against metal ion release results in a reduction in platelet activation.
5
When a platelet comes into contact with the PROBIO
®
coating, it remains in a resting state.
Platelets that come into contact with uncoated stent surfaces have a higher incidence
of adherence and activation.
Reduces Platelet Aggregation
4
Silicon Carbide Coated
Endothelial cells after 24 hours of contact on
silicon carbide: complete endothelialization
with characteristic pavement structure.
Uncoated Metal
Endothelial cells after 24 hours of contact on
uncoated metal: poor coverage with single cells
that show marked pseudopodia.